反应详情

Triethyl phosphite (5.8 ml, 34 mmol) was added to ethyl N-(5-methyl-2-nitrobenzylidene)anthranilate (3.10 g, 9.93 mmol) as obtained in Reference Example 2. The mixture was refluxed under heating for 4 hours, and the triethyl phosphite was evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel using a mixed solvent of hexane/ethyl acetate (5:1), whereby 1.79 g of ethyl 2-(5-methyl-2H-indazol-2-yl)benzoate was obtained.

1. customas obtained in Reference Example 2
2. temperatureThe mixture was refluxed
3. temperatureunder heating for 4 hours
4. customthe triethyl phosphite was evaporated under reduced pressure
5. customThe residue was purified by flash chromatography on silica gel using a mixed solvent of hexane/ethyl acetate (5:1)