HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 274161Generated: October 27, 2026
Chlorodifluoromethane → 1-(Benzyloxy)-4-(difluoromethoxy)benzene
https://huagongshe.com/reaction/274161
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorodifluoromethane | HCID 6372 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[2-[[2-(2,5-Dihydroxyphenyl)phenyl]methoxymethyl]phenyl]benzene-1,4-diol | HCID 131711022 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Benzyloxy)-4-(difluoromethoxy)benzene | HCID 13253412 | — |
Reaction Steps
A mixture of 40.0 g of hydroquinone monobenzyl ether, 40 g of NaOH, 200 ml of water and 300 ml of dioxane are heated to 70° C. with stirring. 35.5 g of chlorodifluoromethane are passed into the cooled mixture with vigorous stirring. The reaction mixture is poured into water, and the product is extracted with petroleum ether. The organic phase is dried over Na2SO4, evaporated, and the residue is chromatographed through a short silica gel column, using petroleum ether/ethyl acetate 8:2 as eluent. A colourless liquid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05389292 |
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| Source dataset | uspto-grants-1995_02 |
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| ORD ID | ord-7520cfc2627e45bcb015516c349ce02e |
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| Source note | uspto-grants-1995_02 |
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