反应详情

温度

70 °C

A mixture of 40.0 g of hydroquinone monobenzyl ether, 40 g of NaOH, 200 ml of water and 300 ml of dioxane are heated to 70° C. with stirring. 35.5 g of chlorodifluoromethane are passed into the cooled mixture with vigorous stirring. The reaction mixture is poured into water, and the product is extracted with petroleum ether. The organic phase is dried over Na2SO4, evaporated, and the residue is chromatographed through a short silica gel column, using petroleum ether/ethyl acetate 8:2 as eluent. A colourless liquid is obtained.

1. extractionthe product is extracted with petroleum ether
2. dry with materialThe organic phase is dried over Na2SO4
3. customevaporated
4. customthe residue is chromatographed through a short silica gel column
5. customA colourless liquid is obtained