反应详情

A mixture of 0.23 mol of 4-(trans-4-pentylcyclohexyl)phenylboric acid, 0.23 mol of 2,6-dichloropyridine, 5 mmol of TPP, 230 ml of a 2 molar sodium carbonate solution and 400 ml of toluene are heated at the boil for 1 hour. The reaction mixture is cooled, and 200 ml of hexane and 200 ml of water are added. The organic phase is separated off, the solvent is removed by evaporation, and the pure product is obtained by chromatography on silica gel using toluene/hexane 3:1 as the eluent.

1. temperatureare heated at the boil for 1 hour
2. temperatureThe reaction mixture is cooled
3. customThe organic phase is separated off
4. customthe solvent is removed by evaporation
5. customthe pure product is obtained by chromatography on silica gel