反应详情

A mixture of 0.1 mol of 2C, 0.1 mol of 1-bromoethoxyethane, 0.1 mol of sodium hydroxide, 20 ml of ethanol and 50 ml of water is heated at the boil for 2 hours. The mixture is cooled, dilute hydrochloric acid is added, and the aqueous phase is extracted with dichloromethane. The solvent is removed under reduced pressure, and the residue is purified by column chromatography, giving the product 2-(4-octyloxyphenyl)-5-(2-ethoxyethoxy)-6-fluoropyridine.

1. temperatureis heated at the boil for 2 hours
2. temperatureThe mixture is cooled
3. extractionthe aqueous phase is extracted with dichloromethane
4. customThe solvent is removed under reduced pressure
5. customthe residue is purified by column chromatography