Chloride → HCID 178527053, compound

HRID 274212Notes

Reaction equation

HRID 274212 reaction equation
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[PH:7](=[O:32])([O-:31])[O:8][CH2:9][C:10](CC1C=CC=CC=1)(CC1C=CC=CC=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Cl-]>C1C=CC=CC=1>[Cl-:2].[PH:7](=[O:32])([O:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[O:31][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 312ChlorideHCID 24819Phosphorus pentachlorideHCID 178527064HCID 178527064, compound

Product 1

HCID 178527053HCID 178527053, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

1 mmole of phosphorus pentachloride in benzene is added to a solution in benzene of 1 mmole of dibenzylphenylethyl phosphonate, which has been previously obtained. The mixture is refluxed at 70° C. for 3 to 4h under an anhydrous atmosphere until the chloride is completely obtained. The benzene of said mixture is then evaporated and is taken up in dichloromethane. This solution is used immediately for carrying out coupling with the peptide.

Workup

  1. customhas been previously obtained
  2. customis completely obtained
  3. customThe benzene of said mixture is then evaporated

Sources & evidence

ORD record
ord-3bf74fd12e054c1f89e8b17e1d9fbd6a
Source dataset
uspto-grants-1995_02
Patent number
US05389612

Reaction notes

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