HCID 178474811, compound → HCID 178474813, compound

HRID 274220Notes

Reaction equation

HRID 274220 reaction equation
C([O:5][C:6](=[O:27])[CH2:7][CH2:8][N:9]([N:13]1[C:17](=[O:18])[C@H:16]([CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH2:25])=[NH:24])[NH:15][C:14]1=[O:26])[C:10](=[O:12])[CH3:11])(C)(C)C>FC(F)(F)C(O)=O>[NH:22]([CH2:21][CH2:20][CH2:19][C@@H:16]1[NH:15][C:14](=[O:26])[N:13]([N:9]([C:10](=[O:12])[CH3:11])[CH2:8][CH2:7][C:6]([OH:27])=[O:5])[C:17]1=[O:18])[C:23]([NH2:25])=[NH:24]

Participants

3

Reactant 1

HCID 178474811HCID 178474811, compound

Product 1

HCID 178474813HCID 178474813, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.3 g of [5-(S)-(3-guanidinopropyl)-2,4-dioxoimidazolidin-3-yl]-acetyl-β-alanine tert-butyl ester are dissolved in 15 ml of 90% strength aqueous trifluoroacetic acid. The mixture is left to stand at room temperature for one hour and concentrated. The residue is dissolved in water and extracted by shaking 3 times with diethyl ether. The aqueous solution is filtered off to remove the insoluble material and freeze-dried.

Workup

  1. waitThe mixture is left
  2. concentrationconcentrated
  3. dissolutionThe residue is dissolved in water
  4. extractionextracted
  5. filtrationThe aqueous solution is filtered off
  6. customto remove the insoluble material
  7. customfreeze-dried

Sources & evidence

ORD record
ord-8c4c0dcb2db6443395975c3ef492dead
Source dataset
uspto-grants-1995_02
Patent number
US05389614

Reaction notes

Loading…