HCID 86748455, compound → HCID 86748454, compound

HRID 274223Notes

Reaction equation

HRID 274223 reaction equation
[C:1]([C:3]1[CH:36]=[CH:35][C:6]([CH:7]=[C:8]2[N:12]([CH3:13])[C:11](=[O:14])[N:10]([N:15]([C:31](=[O:33])[CH3:32])[C@H:16]([C:21]([NH:23][C@H:24]([C:28]([OH:30])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH2:17][C:18](=[O:20])[OH:19])[C:9]2=[O:34])=[CH:5][CH:4]=1)#[N:2]>CO>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH:8]2[N:12]([CH3:13])[C:11](=[O:14])[N:10]([N:15]([C:31](=[O:33])[CH3:32])[C@H:16]([C:21]([NH:23][C@H:24]([C:28]([OH:30])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH2:17][C:18](=[O:19])[OH:20])[C:9]2=[O:34])=[CH:35][CH:36]=1

Participants

3

Reactant 1

HCID 86748455HCID 86748455, compound

Product 1

HCID 86748454HCID 86748454, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

150 mg of (5-(4-cyanobenzylidene)-1-methyl-2,4-dioxoimidazolidin-3-yl)-acetyl-L-aspartyl-L-valine are dissolved in 40 ml of methanol. After addition of 50 mg of 10% strength Pd-on-charcoal, hydrogenation is carried out at room temperature for 12 hours, the catalyst is filtered off, the filtrate is concentrated and the product is freeze-dried.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe product is freeze-dried

Sources & evidence

ORD record
ord-f3743934561c4955b75245b172847a5f
Source dataset
uspto-grants-1995_02
Patent number
US05389614

Reaction notes

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