HCID 86748457, compound → HCID 86748456, compound

HRID 274227Notes

Reaction equation

HRID 274227 reaction equation
[C:1]([C:3]1[CH:35]=[CH:34][C:6]([CH:7]=[C:8]2[NH:12][C:11](=[O:13])[N:10]([N:14]([C:30](=[O:32])[CH3:31])[C@H:15]([C:20]([NH:22][C@H:23]([C:27]([OH:29])=[O:28])[CH:24]([CH3:26])[CH3:25])=[O:21])[CH2:16][C:17](=[O:19])[OH:18])[C:9]2=[O:33])=[CH:5][CH:4]=1)#[N:2]>CO>[NH2:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH:8]2[NH:12][C:11](=[O:13])[N:10]([N:14]([C:30](=[O:32])[CH3:31])[C@H:15]([C:20]([NH:22][C@H:23]([C:27]([OH:29])=[O:28])[CH:24]([CH3:26])[CH3:25])=[O:21])[CH2:16][C:17](=[O:18])[OH:19])[C:9]2=[O:33])=[CH:34][CH:35]=1

Participants

3

Reactant 1

HCID 86748457HCID 86748457, compound

Product 1

HCID 86748456HCID 86748456, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

400 mg of (5-(4-cyanobenzylidene)-2,4-dioxoimidazolidin-3-yl)-acetyl-L-aspartyl-L-valine are dissolved in 60 ml of methanol. After addition of 50 mg of 10% strength Pd-on-charcoal, hydrogenation is carried out at room temperature for 12 hours, the catalyst is filtered off, the filtrate is concentrated and the product is freeze-dried.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe product is freeze-dried

Sources & evidence

ORD record
ord-702cd760efef419a878094daa2c411db
Source dataset
uspto-grants-1995_02
Patent number
US05389614

Reaction notes

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