4-Bromophenol → HCID 67783769, compound

HRID 274260Notes

Reaction equation

[OH:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[CH:26]([NH:27][C:28](=[O:37])[CH2:29][O:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25](=[O:38])[N:7]2[C:8]=1[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].[CH:39]1[C:44](O)=[CH:43][CH:42]=[C:41]([Br:46])[CH:40]=1>>[Br:46][C:41]1[CH:42]=[CH:43][C:44]([O:1][CH2:2][C:3]2[CH2:4][S:5][C@@H:6]3[CH:26]([NH:27][C:28](=[O:37])[CH2:29][O:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:25](=[O:38])[N:7]3[C:8]=2[C:9]([O:11][CH:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:10])=[CH:39][CH:40]=1

Participants

Reactant 2

HCID 78084-Bromophenol

HCID 67783388HCID 67783388, compound

Product 1

HCID 67783769HCID 67783769, compound

Procedure

The procedure described in Example 1(a) was repeated, but using 2.00 g of diphenylmethyl 3-hydroxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate and p-bromophenol, to afford 420 mg of the title compound as a powder.

Sources & evidence

ORD record: ord-9937bcec5fdd48d1b2a3c4c1416df410
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05389626

Reaction notes

Loading…