Ethyl acetate hexane → HCID 57299791, compound

HRID 274306Notes

Reaction equation

HRID 274306 reaction equation
[OH:1][C@@H:2]1[C@H:7]2[C@H:8]3[C@H:18]([CH2:19][CH2:20][C@:5]2([CH3:6])[C:4](=[O:23])[CH2:3]1)[C@:16]1([CH3:17])[C:11](=[C:12]([CH3:22])[C:13](=[O:21])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3.CCCCCC.[C:30](OCC)(=[O:32])[CH3:31]>>[C:30]([O:1][C@@H:2]1[C@H:7]2[C@H:8]3[C@H:18]([CH2:19][CH2:20][C@:5]2([CH3:6])[C:4](=[O:23])[CH2:3]1)[C@:16]1([CH3:17])[C:11](=[C:12]([CH3:22])[C:13](=[O:21])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3)(=[O:32])[CH3:31]

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 57088357HCID 57088357, compound

Product 1

HCID 57299791HCID 57299791, compound

Procedure

4.2 g of 15α-hydroxy-4-methylandrost-4-ene-3,17-dione is acetylated analogously to Example 1(a). Chromatography of the crude product on silica gel with a hexane-ethyl acetate gradient yields 3.9 g of 15α-acetoxy-4-methylandrost-4-ene-3,17-dione.

Sources & evidence

ORD record
ord-44e00be4a6da4fa28e40d9e17c37a96f
Source dataset
uspto-grants-1995_02
Patent number
US05389624

Reaction notes

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