反应详情

The 2-bromo-4'-chloropropiophenone (58.1 g), which had been prepared in Example 5, and triphenyl phosphine (61.6 g) were dissolved in 250 ml of acetonitrile. The resulting solution was heated under reflex for 1.5 hours. After the completion of the reaction, the reaction mixture was cooled with ice, and the crystalline material thus formed was separated by filtration, washed with cold acetonitrile and dried in air to give triphenyl[1-(4-chlorophenyl)-1-oxo-2-propyl]-phosphonium bromide (79.0 g). mp 258°-258.5° C.

1. temperatureThe resulting solution was heated under reflex for 1.5 hours
2. customAfter the completion of the reaction
3. temperaturethe reaction mixture was cooled with ice
4. customthe crystalline material thus formed
5. customwas separated by filtration
6. washwashed with cold acetonitrile
7. customdried in air