反应详情

Add 0.5 g of lithium aluminum hydride to a solution of 2.8 g 7-(4-chlorobenzyl)-perhydroazepin -2-one in 30 ml of tetrahydrofurane. Boil the mixture under reflux for 16 hours, cool it and then carefully treat it with ice-water. After extraction with diethyl ether, dry the extract over sodium sulfate concentrate the oily residue and distill in a vacuum to obtain 1.8 g of the title compound with a BP of 90° to 92° at 0.05 mm Hg.

1. temperatureBoil the mixture under reflux for 16 hours
2. temperaturecool it
3. extractionAfter extraction with diethyl ether
4. customdry the
5. extractionextract over sodium sulfate
6. concentrationconcentrate the oily residue
7. distillationdistill in a vacuum