7-(4-Methylbenzyl)perhydroazepin-2-one → 2-(4-Methylbenzyl)azepane

HRID 27439Notes

Reaction equation

HRID 27439 reaction equation
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][CH:7]2[NH:13][C:12](=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 123493267-(4-Methylbenzyl)perhydroazepin-2-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 42391592-(4-Methylbenzyl)azepane

Procedure

Using the mode of operation described in Example 52 obtain 1.6 g of the title compound as oil with a BP of 82° to 85° at 0.01 mm Hg from 2.8 of 7-(4-methylbenzyl)perhydroazepin-2-one and 0.5 of g lithium aluminum hydride.

Sources & evidence

ORD record
ord-f00fcf268c734d1c997807c59e15a786
Source dataset
uspto-grants-1980_09
Patent number
US04221788

Reaction notes

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