Ethoxyacetic acid → HCID 15224441, compound

HRID 274393Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:15][CH2:16][C:17]([OH:20])([CH3:19])[CH3:18])=[C:7]([N+:12]([O-])=O)[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:21]([O:23][CH2:24][C:25](O)=O)[CH3:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:15]([CH2:16][C:17]([CH3:19])([CH3:18])[OH:20])[C:22]([CH2:21][O:23][CH2:24][CH3:25])=[N:12][C:7]=3[CH:8]=[N:9][C:10]=2[CH:11]=1

Participants

Reactant 2

HCID 12301Ethoxyacetic acid

HCID 15224440HCID 15224440, compound

Product 1

HCID 15224441HCID 15224441, compound

Procedure

Using the general method of Example 42, 7-chloro-4-(2-hydroxy-2-methylpropylamino)-3-nitroquinoline (18.5 g, 63 mmol, Example 82) was reduced and the resulting diamine reacted with ethoxyacetic acid to provide the desired product as a thick, green oil.

Sources & evidence

ORD record: ord-8bf79719cd864b9da428f12b05670462
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05389640

Reaction notes

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