反应详情

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194° uv λmax 276 nm (H2O, pH 5.5).

1. filtrationThe precipitate was filtered
2. customneutralized with anhydrous sodium acetate at 5°
3. washwashed with a little cold water (3 times)
4. customRecrystallization from ethanol/H2O
5. customgave colorless crystals