Ammonium Chloride → HCID 178488256, compound

HRID 274516Notes

Reaction equation

HRID 274516 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([N+:13]([O-:15])=[O:14])[C:10]=1[O:11]C)[C:6]#[N:7].[Cl-].[NH4+].[N-:18]=[N+:19]=[N-:20].[Na+]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]2[NH:20][N:19]=[N:18][N:7]=2)[CH:8]=[C:9]([N+:13]([O-:15])=[O:14])[C:10]=1[OH:11]

Participants

5

Reactant 3

HCID 25517Ammonium Chloride2×HCID 33557Sodium Azide2×HCID 214590491222880-77-4

Product 1

HCID 178488256HCID 178488256, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.0 g of 3,4-dimethoxy-5-nitro-benzonitrile are dissolved in 50 ml of dimethylformamide, whereupon the solution is treated with 1.66 g of ammonium chloride and 2.02 g of sodium azide and stirred at 125° for 31 hours. After in each case 8 and 15 hours the same amounts of ammonium chloride and sodium azide are added thereto. After cooling the mixture is poured on to ice. The separated precipitate is filtered under suction, washed with water and dried. There is obtained 2-methoxy-6-nitro-4-(1H-tetrazol-5-yl)phenol in the form of orange crystals of m.p. >240° (dec.).

Workup

  1. temperatureAfter cooling the mixture
  2. additionis poured on to ice
  3. filtrationThe separated precipitate is filtered under suction
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-bb2e12d49b9f4b7a9b3b8c3eef73edfa
Source dataset
uspto-grants-1995_02
Patent number
US05389653

Reaction notes

Loading…