HCID 21459008, compound → HCID 21459031, compound

HRID 274527Notes

Reaction equation

HRID 274527 reaction equation
[OH:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[O:7])=[CH:4][C:3]=1[O:23]C>Br>[OH:23][C:3]1[CH:4]=[C:5]([CH:18]=[C:19]([N+:20]([O-:22])=[O:21])[C:2]=1[OH:1])[C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 1

HCID 21459008HCID 21459008, compound

Product 1

HCID 21459031HCID 21459031, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

2.0 g of 4-hydroxy-3-methoxy-5-nitro-4'-(trifluoromethyl)benzophenone (dissolved in 20 ml of 33 percent hydrobromic acid in glacial acetic acid) are stirred at 90° for 18 hours. Thereupon. 20 ml of 48 percent aqueous hydrobromic acid are added thereto, whereupon the mixture is stirred at 110° for an additional 18 hours. The reaction mixture is subsequently evaporated under reduced pressure and the residue is recrystallized from water. There is obtained 3,4-dihydroxy-5-nitro-4'-(trifluoromethyl)benzophenone of melting point 116°-118°.

Workup

  1. customThe reaction mixture is subsequently evaporated under reduced pressure
  2. customthe residue is recrystallized from water

Sources & evidence

ORD record
ord-3151bb653e9243b6b58176a2126a0b28
Source dataset
uspto-grants-1995_02
Patent number
US05389653

Reaction notes

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