Hydrogen Bromide → HCID 135609941, compound

HRID 274531Notes

Reaction equation

HRID 274531 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[C:12]([O:18]C)=[C:11]([O:20]C)[CH:10]=1)=[O:8].[BrH:22]>>[BrH:22].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([C:9]1[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[C:12]([OH:18])=[C:11]([OH:20])[CH:10]=1)=[O:8]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19000174HCID 19000174, compound

Product 1

HCID 135609941HCID 135609941, compound

Procedure

5.0 g of 3,4-dimethoxy-5-nitrophenyl (1-methylimidazol-2-yl) ketone are treated with 50 ml of hydrobromic acid (48%), whereupon the mixture is stirred under reflux temperature for 2 hours. After cooling the separated precipitate is filtered under suction, washed with ice-water and recrystallized from ethanol. There is obtained 3,4-dihydroxy-5-nitrophenyl (1-methyl- imidazol-2-yl) ketone hydrobromide in the form of yellow crystals of decomposition point >240°.

Workup

  1. temperatureunder reflux temperature for 2 hours
  2. temperatureAfter cooling the separated precipitate
  3. filtrationis filtered under suction
  4. washwashed with ice-water
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-8408955cade34914892d5328d037e7e4
Source dataset
uspto-grants-1995_02
Patent number
US05389653

Reaction notes

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