反应详情

2 g of 3,4-dimethoxy-5-nitrophenyl 2-thienyl ketone are stirred at 100° for 8 hours in a mixture of 20 ml of 30-33 percent hydrobromic acid in glacial acetic acid and 20 ml of 48 percent aqueous hydrobromic acid. The reaction mixture is subsequently evaporated to dryness. The residue is taken up in ethyl acetate, washed with water, dried over sodium sulfate and filtered, and the filtrate is evaporated. After recrystallization from ethyl acetate/hexane there is obtained 3,4-dihydroxy-5-nitrophenyl 2-thienyl ketone of m.p. 155°-157°.

1. customThe reaction mixture is subsequently evaporated to dryness
2. washwashed with water
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customthe filtrate is evaporated
6. customAfter recrystallization from ethyl acetate/hexane there