反应详情

A mixture of 12 g of 7-(propionamido)-2-(4-carboxyphenyl)-4H-3,1-benzoxazine-4-one, 120 ml of absolute ethanol and 9 ml of triethylamine was heated under reflux for a period of 8 hours. After being allowed to cool, the mixture was added with 9 ml of acetic acid and 500 ml of water, the precipitating crystal was filtered, and recrystallized from a solvent mixture of ethanol and water to yield 10 g of ethyl 2-(4-carboxybenzamido)-4-propionamidobenzoate having a melting point in the range of from 246° to 248° C.

1. temperaturewas heated
2. temperatureunder reflux for a period of 8 hours
3. temperatureto cool
4. filtrationthe precipitating crystal was filtered
5. customrecrystallized from a solvent mixture of ethanol and water