Water → Propyl 2-(4-carboxybenzamido)-4-propionamidobenzoate

HRID 27469Notes

Reaction equation

HRID 27469 reaction equation
[C:1]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[C:10](=[O:23])[O:11][C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=3)=[N:13][C:8]=2[CH:7]=1)(=[O:4])[CH2:2][CH3:3].[CH2:26]([OH:29])[CH2:27][CH3:28].O1CCOCC1.[OH2:36]>>[C:20]([C:17]1[CH:16]=[CH:15][C:14]([C:12]([NH:13][C:8]2[CH:7]=[C:6]([NH:5][C:1](=[O:4])[CH2:2][CH3:3])[CH:25]=[CH:24][C:9]=2[C:10]([O:29][CH2:26][CH2:27][CH3:28])=[O:23])=[O:11])=[CH:19][CH:18]=1)([OH:22])=[O:36]

Participants

5

Reactant 4

HCID 962WaterHCID 10311-PropanolHCID 312751,4-DioxaneHCID 130200727-(propionamido)-2-(4-carboxyphenyl)-4H-3,1-benzoxazine-4-one

Product 1

HCID 13020073Propyl 2-(4-carboxybenzamido)-4-propionamidobenzoateYield 80%

Procedure

The procedure of Example 1 was repeated for reacting 7-(propionamido)-2-(4-carboxyphenyl)-4H-3,1-benzoxazine-4-one with n-propanol, and the reaction product was treated as in Example 1 except that the solvent for recrystallization was a mixture of dioxane and water. The product obtained was a 80% yield of propyl 2-(4-carboxybenzamido)-4-propionamidobenzoate having a melting point in the range of from 233° to 235° C.

Workup

  1. additionthe reaction product was treated as in Example 1 except that the solvent for recrystallization
  2. customThe product obtained

Sources & evidence

ORD record
ord-566395d642ee45daaa6f4f8d8acfbb15
Source dataset
uspto-grants-1980_09
Patent number
US04221814

Reaction notes

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