反应详情

A mixture of ethyl 4-(2,3-dichlorophenyl)pyrrole-3-carboxylate (5.95 g, 21 mmol) and potassium hydroxide (6.5 g, 85%, 99 mmol) is heated at reflux for 6 hours, cooled, diluted with water and washed with diethyl ether. The aqueous phase is acidified with hydrochloric acid and filtered to obtain a solid. The solid is washed with diethyl ether and petroleum ether and dried to give the title product as a white solid (5.24 g) which is identified by 1H and 13C NMR spectral analyses.

1. temperatureis heated
2. temperatureat reflux for 6 hours
3. temperaturecooled
4. washwashed with diethyl ether
5. filtrationfiltered
6. customto obtain a solid
7. washThe solid is washed with diethyl ether and petroleum ether
8. customdried