Potassium Hydroxide → 4-(2,3-Dichlorophenyl)-1H-pyrrole-3-carboxylic acid

Participants

Reaction Steps

A mixture of ethyl 4-(2,3-dichlorophenyl)pyrrole-3-carboxylate (5.95 g, 21 mmol) and potassium hydroxide (6.5 g, 85%, 99 mmol) is heated at reflux for 6 hours, cooled, diluted with water and washed with diethyl ether. The aqueous phase is acidified with hydrochloric acid and filtered to obtain a solid. The solid is washed with diethyl ether and petroleum ether and dried to give the title product as a white solid (5.24 g) which is identified by 1H and 13C NMR spectral analyses.

Provenance & Evidence