反应详情

温度

100 °C

1 g (6.015 mmol) of 8-thiochromanol is dissolved in 2.26 g (12.03 mmol) of 1,2-dibromoethane. 5.6 cm3 of a 1.6N NaOH solution are added dropwise. The mixture is heated to 100° C.; after 2 hours, the solution reaches pH 7. The mixture is allowed to cool. 100 cm3 of a 2N NaOH solution are added. The mixture is extracted with CH2Cl2 and then dried over MgSO4. Purification over a silica column (eluant: petroleum ether/CH2Cl2 2: 1) yields the desired compound.

1. temperatureto cool
2. extractionThe mixture is extracted with CH2Cl2
3. dry with materialdried over MgSO4
4. customPurification over a silica column (eluant: petroleum ether/CH2Cl2 2: 1)