HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 274745Generated: October 30, 2026
1,2-Dibromoethane → 8-(2-Bromoethoxy)-3,4-dihydro-2H-1-benzothiopyran
https://huagongshe.com/reaction/274745
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3,4-dihydro-2H-1-benzothiopyran-8-ol | HCID 121617 | — |
| Product | 8-(2-Bromoethoxy)-3,4-dihydro-2H-1-benzothiopyran | HCID 15295832 | 32% |
Reaction Steps
1 g (6.015 mmol) of 8-thiochromanol is dissolved in 2.26 g (12.03 mmol) of 1,2-dibromoethane. 5.6 cm3 of a 1.6N NaOH solution are added dropwise. The mixture is heated to 100° C.; after 2 hours, the solution reaches pH 7. The mixture is allowed to cool. 100 cm3 of a 2N NaOH solution are added. The mixture is extracted with CH2Cl2 and then dried over MgSO4. Purification over a silica column (eluant: petroleum ether/CH2Cl2 2: 1) yields the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05389668 |
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| Source dataset | uspto-grants-1995_02 |
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| ORD ID | ord-605aec7647544ba68b6e903e35942b72 |
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| Source note | uspto-grants-1995_02 |
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