Hydrochloric Acid → HCID 86747808, compound

HRID 274858Notes

Reaction equation

HRID 274858 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH2:10][CH2:11][NH:12][C:13]([NH2:18])=[N:14][N+:15]([O-:17])=[O:16])=[CH:4][CH:3]=1.[CH2:19]=O.Cl>O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:10][CH2:11][N:12]([C:13]([NH2:18])=[N:14][N+:15]([O-:17])=[O:16])[CH2:19]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 136378389HCID 136378389, compound

Product 1

HCID 86747808HCID 86747808, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture consisting of 1-{2-(6-chloro-3-pyridylmethylamino)ethyl}-2-nitroguanidine (1 g), a 37% aqueous solution of formalin (0.35 g), catalytic amount of hydrochloric acid, and water (20 ml) was stirred at 50° C. for one hour. After cooling, the solvent was removed from the reaction mixture under reduced pressure, leaving crystals that were then washed with chloroform to obtain the 1-(6-chloro-3-pyridylmethyl)-3-{1-(nitroimino)-aminomethyl}-imidazolidine. mp 170°-174° C.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was removed from the reaction mixture under reduced pressure
  3. customleaving crystals that
  4. washwere then washed with chloroform

Sources & evidence

ORD record
ord-2dd56c3be80b45e58ae72acfd5cc0a1c
Source dataset
uspto-grants-1995_02
Patent number
US05391562

Reaction notes

Loading…