Dimethylcarbamoyl Chloride → HCID 15239992, compound

HRID 274880Notes

Reaction equation

HRID 274880 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[N+:11]([O-])[C:10]=1[C:16]([O:18][CH3:19])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][N:21](C)[C:22](Cl)=O>ClCCl>[CH2:1]([O:8][C:9]1[C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:11][C:12]([N:21]([CH3:22])[CH3:20])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6598Dimethylcarbamoyl ChlorideHCID 15239991HCID 15239991, compound

Product 1

HCID 15239992HCID 15239992, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

15 g (58 mmol) of methyl 3-benzyloxypicolinate-N-oxide, 6.7 g (67 mmol) of trimethylsilylnitrile and 8.3 g (61 mmol) of N,N-dimethylcarbamoyl chloride were added to 100 ml of dichloromethane, and the mixture was allowed to stand at room temperature while stirring. The organic layer obtained was washed with water, dried and concentrated, and the residue thus obtained was purified by column chromatography to obtain an aimed compound.

Workup

  1. customto stand at room temperature
  2. customThe organic layer obtained
  3. washwas washed with water
  4. customdried
  5. concentrationconcentrated
  6. customthe residue thus obtained
  7. customwas purified by column chromatography

Sources & evidence

ORD record
ord-61d8bc3577cd4b70a9c7b52ce6bae0ef
Source dataset
uspto-grants-1995_02
Patent number
US05391537

Reaction notes

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