Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol | HCID 22122104 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone | HCID 22122090 | 62% |
반응 단계
A solution of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol (5.4 g, 20 mmole) in acetone-1N hydrochloric acid (1:1) was stirred for 4 hr. The acetone was removed in vacuo and the crude material crystallized from isopropyl ether to give the product (62%, mp: 84°-85 ° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05391570 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-8ad1fdc27a024346ac3b82be898e7dc1 |
| 출처 메모 | uspto-grants-1995_02 |