反应详情

Cesium carbonate (814.5 mg, 2.5 mmol) was added to a stirred solution of benzimidazolinone (335 mg, 2.5 mmol) in DMF (10 mL) under nitrogen at room temperature. After stirring for 30 min., methyl iodide (355 mg, 2.5 mmol) was added and the mixture stirred at room temperature for 18 h. Water was added and the mixture extracted with ethyl acetate. The organic phase was washed with water, dried (magnesium sulfate) and the solvent removed in vacuo. The residue was chromatographed (10-50% ethyl acetate/hexane) to give the title compound (43 mg, 12%) as a white solid.

1. stirringthe mixture stirred at room temperature for 18 h
2. extractionthe mixture extracted with ethyl acetate
3. washThe organic phase was washed with water
4. dry with materialdried (magnesium sulfate)
5. customthe solvent removed in vacuo
6. customThe residue was chromatographed (10-50% ethyl acetate/hexane)