反应详情

To a solution of 0.280 g (1.40 mmol) of the product of step C and 0.762 g () of methyl α-bromo-3,4-methylenedioxyphenylacetate in 3.0 mL of acetone was added 0.386 g (2.80 mmol) of finely powdered potassium carbonate and the mixture was stirred and heated at reflux for 2 hours. At this point, the reaction mixture was cooled to room temperature, filtered, and evaporated in vacuo. The residue was purified on a silica gel flash chromatography column eluted with 30% EtOAc-hexane. Evaporation of the purified fractions and solvent removal in vacuo afforded 0.445 g (81%) of the title compound.

1. temperatureheated
2. temperatureat reflux for 2 hours
3. filtrationfiltered
4. customevaporated in vacuo
5. customThe residue was purified on a silica gel flash chromatography column
6. washeluted with 30% EtOAc-hexane
7. customEvaporation of the purified fractions and solvent removal in vacuo