Acetic Anhydride → HCID 54027150, compound

HRID 274954Notes

Reaction equation

HRID 274954 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]([NH:5][C@H:6]([C:17]([OH:19])=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)=[O:4].[C:22](OC(=O)C)(=[O:24])[CH3:23].[H][H]>[Pd].C(O)(=O)C>[F:1][C:2]([F:21])([F:20])[C:3]([NH:5][C@H:6]([C:17]([OH:19])=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:22](=[O:24])[CH3:23])=[CH:10][CH:9]=1)=[O:4]

Participants

6

Reactant 3

HCID 7918Acetic AnhydrideHCID 54228721HCID 54228721, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54027150HCID 54027150, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 60.8 g (0.2 Mol) of N-trifluoroacetyl-4-nitro-phenylalanine, 250 ml of glacial acetic acid, 94 ml (1.0 Mol) of acetic anhydride and 10 g 10% palladium/charcoal is hydrogenated for 5 hours at 50° C. under 5 bars of hydrogen. The mixture is then suction filtered and the filtrate is evaporated to dryness.

Workup

  1. filtrationsuction filtered
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-e081c695b4ab4f49aedbfa7ac8ad69ee
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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