1,8-Naphthosultone → HCID 178428645, compound

HRID 274960Notes

Reaction equation

HRID 274960 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH2:21])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH:22]1[CH:27]=[C:26]2[O:28][S:29]([C:32]3=[CH:33][CH:34]=[CH:35][C:24](=[C:25]23)[CH:23]=1)(=[O:31])=[O:30]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH:21][S:29]([C:32]3[C:25]4[C:24](=[CH:23][CH:22]=[CH:27][C:26]=4[OH:28])[CH:35]=[CH:34][CH:33]=3)(=[O:31])=[O:30])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 657441,8-NaphthosultoneHCID 178428665HCID 178428665, compound

Product 1

HCID 178428645HCID 178428645, compound

Conditions

Temperature
100 °C

Procedure

Prepared from 1-(1H-benzimidazol-5-yl-methyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethylamine and 1,8naphthalene sultone by heating to 100° C. for 30 minutes and subsequently heating to 140° C. for 20 minutes. After cooling, the product obtained is purified over a silica gel column (eluant: ethyl acetate/methanol=9:1).

Workup

  1. temperaturesubsequently heating to 140° C. for 20 minutes
  2. temperatureAfter cooling
  3. customthe product obtained
  4. customis purified over a silica gel column (eluant: ethyl acetate/methanol=9:1)

Sources & evidence

ORD record
ord-c1a76724d6cd4cb5ae7c96342e548a00
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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