Acetyl chloride → HCID 178474564, compound

HRID 274976Notes

Reaction equation

HRID 274976 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:24][C:25]2[CH:33]=[CH:32][C:28]3[NH:29][CH:30]=[N:31][C:27]=3[CH:26]=2)[C:14]([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][CH3:23])[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:34].C(Cl)(=O)C.[O:39]1[CH2:44][CH2:43]OCC1>C(N(CC)CC)C>[NH2:1][C:2]1[C:3]([Cl:34])=[CH:4][C:5]([S:9]([NH:12][CH:13]([CH2:24][C:25]2[CH:33]=[CH:32][C:28]3[NH:29][CH:30]=[N:31][C:27]=3[CH:26]=2)[C:14]([N:16]2[CH2:17][CH2:18][CH:19]([N:22]([CH3:23])[C:44](=[O:39])[CH3:43])[CH2:20][CH2:21]2)=[O:15])(=[O:10])=[O:11])=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 312751,4-DioxaneHCID 178482260HCID 178482260, compound

Product 1

HCID 178474564HCID 178474564, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared from 4-amino-N-[1-(1H-benzimidazol-5-yl-methyl)-2-(4-methylamino-piperidin-1-yl)-2-oxo-ethyl]-3,5-dichloro-benzenesulphonamide and acetylchloride in dioxane and triethylamine analogously to Example 2.

Sources & evidence

ORD record
ord-afcd17d1bbc34721a92d50d3a468a3f4
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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