Phosphorus oxychloride → HCID 178510224, compound

HRID 274982Notes

Reaction equation

[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:25][C:26]2[CH:34]=[CH:33][C:29]3[NH:30][CH:31]=[N:32][C:28]=3[CH:27]=2)[C:14]([N:16]2[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=O)[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:35].P(Cl)(Cl)(Cl)=O>>[NH2:1][C:2]1[C:3]([Cl:35])=[CH:4][C:5]([S:9]([NH:12][CH:13]([CH2:25][C:26]2[CH:34]=[CH:33][C:29]3[NH:30][CH:31]=[N:32][C:28]=3[CH:27]=2)[C:14]([N:16]2[CH2:21][CH2:20][CH:19]([C:22]#[N:24])[CH2:18][CH2:17]2)=[O:15])(=[O:10])=[O:11])=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178513688HCID 178513688, compound

Product 1

HCID 178510224HCID 178510224, compound

Procedure

Prepared from 4-amino-N-[1-(1H-benzimidazol-5-ylmethyl)-2-(4-aminocarbonyl-piperidin-1-yl)-2-oxo-ethyl]-3,5-dichloro-benzenesulphonamide by reacting with phosphorusoxychloride at ambient temperature.

Sources & evidence

ORD record: ord-5ab0158d59f84adaaa55cb12498a5d81
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05391556

Reaction notes

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