Ethylenediamine → HCID 178484971, compound

HRID 27501Notes

Reaction equation

HRID 27501 reaction equation
BrCC1C=CNN=1.C(N)CN.[NH:12]1[CH:16]=[CH:15][C:14]([CH2:17][NH:18][CH2:19][CH2:20][NH2:21])=[N:13]1.[C:22]([NH:24][C:25](=[N:28][CH3:29])SC)#[N:23]>>[C:22]([NH:24][C:25]([NH:28][CH3:29])=[N:21][CH2:20][CH2:19][NH:18][CH2:17][C:14]1[CH:15]=[CH:16][NH:12][N:13]=1)#[N:23]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 1111031-Cyano-2,3-dimethylisothioureaHCID 1784195145-(Bromomethyl)-1H-pyrazoleHCID 178511340HCID 178511340, compound

Product 1

HCID 178484971HCID 178484971, compound

Procedure

Reacting 3-bromomethylpyrazole with ethylenediamine by the procedure of Example 34 and reacting the resulting N-(3-pyrazolylmethyl)ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(d) gives N-cyano-N'-methyl-N"-[2-(3-pyrazolylmethylamino)ethyl]guanidine. Hydrolysis of this compound by the procedure of Example 3(e) gives N-methyl-N'-[2-(3-pyrazolylmethylamino)ethyl]guanidine trihydrochloride.

Sources & evidence

ORD record
ord-d926bcb70309478bb2c38f6c76e10893
Source dataset
uspto-grants-1980_09
Patent number
US04221802

Reaction notes

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