反应详情

A mixture containing 2.1 g of 6-acetyl-2,2-dimethyl-3,4-epoxychromane and 1.7 g of 2-hydroxypyridine in 40 ml of tetrahydrofuran is refluxed for 16 hours in the presence of 0.4 ml of benzyltrimethylammonium hydroxide. The mixture is cooled and the crystals formed are filtered off and washed with tetrahydrofuran. After drying under vacuum at 60° C., 1.5 g of the expected product are obtained.

1. temperatureThe mixture is cooled
2. customthe crystals formed
3. filtrationare filtered off
4. washwashed with tetrahydrofuran
5. customAfter drying under vacuum at 60° C.