反应详情

To a 300 ml round bottom flask is added 14.5 g (0.1 mole) of 7-hydroxyisoquinoline and 100 ml of warmed tetramethylene sulfone. The brown slurry is stirred and to it is added portionwise 18.6 g (0.14 mole) of nitronium tetrafluoroborate with cooling (ice bath). The reaction is stirred for 3 hours. The reaction is then quenched with 100 ml of methanol, evaporated to dryness and triturated twice with ether to precipitate a dark solid (19.0 g, 100%).

1. temperaturewith cooling (ice bath)
2. stirringThe reaction is stirred for 3 hours
3. customThe reaction is then quenched with 100 ml of methanol
4. customevaporated to dryness
5. customtriturated twice with ether
6. customto precipitate a dark solid (19.0 g, 100%)