反应详情

3.62 mmol of 2-fluoro-naphthacene-5,12-dione (prepared according to U.S. Pat. No. 4,522,754), 3.98 mmol of NaSCH3, 10.86 mmol of potassium carbonate and 10 ml of DMSO are stirred at 25° C. for 3 minutes. The mixture is poured onto water. The crystals are filtered off and dissolved in tetrahydrofuran/toluene and the solution is dried over sodium sulfate and evaporated. The residue is recrystallized from THF/toluene/pentane. Yield 1 g (83%); melting point 195°-196° C.

1. additionThe mixture is poured onto water
2. filtrationThe crystals are filtered off
3. dissolutiondissolved in tetrahydrofuran/toluene
4. dry with materialthe solution is dried over sodium sulfate
5. customevaporated
6. customThe residue is recrystallized from THF/toluene/pentane