1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 20089993, compound

HRID 275209Notes

Reaction equation

HRID 275209 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:15][CH:14]1[CH2:13][CH2:12][NH:11][CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:16]1([N:19]2[C:28]3[C:23](=[CH:24][C:25]([F:30])=[C:26](F)[CH:27]=3)[C:22](=[O:31])[C:21]([C:32]([OH:34])=[O:33])=[CH:20]2)[CH2:18][CH2:17]1>>[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:15][CH:14]1[CH2:13][CH2:12][N:11]([C:26]1[CH:27]=[C:28]3[C:23]([C:22](=[O:31])[C:21]([C:32]([OH:34])=[O:33])=[CH:20][N:19]3[CH:16]3[CH2:18][CH2:17]3)=[CH:24][C:25]=1[F:30])[CH2:10]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 52104221-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 20089946tert-Butyl 3-azabicyclo[4.1.0]heptan-1-ylcarbamate

Product 1

HCID 20089993HCID 20089993, compoundYield 65%

Procedure

According to the procedure of Example 34A, 1-tert-butoxycarbonylamino-3-azabicyclo[4.1.0]heptane (270.0 mg, 1.27 mmol) and 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (275.6 mg, 1.03 mmol were reacted to generate the title compound (304.2 mg, 0.666 mmol, 65%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-70c8ea3b8d484486ab1944114be6b6ac
Source dataset
uspto-grants-1995_02
Patent number
US05391763

Reaction notes

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