8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide → HCID 86746507, compound

HRID 275302Notes

Reaction equation

HRID 275302 reaction equation
[C:1]1([S:7]([NH:10][CH2:11][CH2:12][C:13]([O:15]C)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:17][C:18]1[CH:36]=[CH:35][C:21]2[O:22][C:23]3[CH:34]=[CH:33][CH:32]=[CH:31][C:24]=3[CH2:25][N:26]([C:27]([NH:29][NH2:30])=[O:28])[C:20]=2[CH:19]=1>>[C:1]1([S:7]([NH:10][CH2:11][CH2:12][C:13]([NH:30][NH:29][C:27]([N:26]2[CH2:25][C:24]3[CH:31]=[CH:32][CH:33]=[CH:34][C:23]=3[O:22][C:21]3[CH:35]=[CH:36][C:18]([Cl:17])=[CH:19][C:20]2=3)=[O:28])=[O:15])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 135604618-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazideHCID 19800028HCID 19800028, compound

Product 1

HCID 86746507HCID 86746507, compound

Procedure

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[3-[(phenylsulfonyl)amino]-1-oxopropyl]hydrazide (24) was prepared from N-(phenylsulfonyl)-β-alanine, methyl ester (23), prepared as described above in Example 23, and 8-chlorodibenz[b,f][1,4]-oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, on a two mmol scale in the manner described in Example 18 above to yield 0.44 g (44%) of product.

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-f3472cf2df5f41aea97c1e87857e4626
Source dataset
uspto-grants-1995_02
Patent number
US05393747

Reaction notes

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