Lawesson's reagent → HCID 25142691, compound

HRID 275323Notes

Reaction equation

HRID 275323 reaction equation
[CH3:1][N:2]1[C:10](=O)[C:9]2[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:7]=[N:6][C:5]=2[N:4]2[C@H:19]3[CH2:24][CH2:23][CH2:22][C@H:20]3[N:21]=[C:3]12.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>C1(C)C(C)=CC=CC=1>[CH3:1][N:2]1[C:10](=[S:34])[C:9]2[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:7]=[N:6][C:5]=2[N:4]2[C@H:19]3[CH2:24][CH2:23][CH2:22][C@H:20]3[N:21]=[C:3]12

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 10496436HCID 10496436, compound

Product 1

HCID 25142691HCID 25142691, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Treat cis-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylmethyl) cyclopenta[4,5]imidazo[2,1-b]purin-4(3H)-one (0.16 g=0.5 mmol) with Lawesson's reagent (0.2 g=0.5 mmol) in xylene overnight. Remove solvent and chromatograph on silica, eluting with 98:2 CH2Cl2 /MeOH to give the title compound as a yellow foam. FAB MS: M+1=338.

Workup

  1. washRemove solvent and chromatograph on silica, eluting with 98:2 CH2Cl2 /MeOH

Sources & evidence

ORD record
ord-590790263dba4f8483e53bad9935b6ae
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

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