Sodium Hydroxide → HCID 14969707, compound

HRID 275338Notes

Reaction equation

HRID 275338 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](SC)[N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:4](=[O:17])[CH:3]=1.[OH-:18].[Na+]>>[NH2:1][C:2]1[NH:7][C:6](=[O:18])[N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:4](=[O:17])[CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 200878306-Amino-3-benzyl-2-(methylsulfanyl)pyrimidin-4(3H)-one

Product 1

HCID 14969707HCID 14969707, compound

Procedure

Reflux 6-amino-3-(phenylmethyl)-2-methylthiopyrimidin-4(3H)-one (2.5 g=10 mmol) in 40 ml 10% aqueous NaOH for four hours. Cool, acidify the solution and collect the precipitate. Water wash and dry to give the title compound, a white solid, EI MS: M+=217.

Workup

  1. temperatureCool
  2. customcollect the precipitate
  3. washWater wash
  4. customdry

Sources & evidence

ORD record
ord-c7f84f230282458da550577707bb6e2e
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

Loading…