rac-(1R,2R)-2-aminocyclopentan-1-ol → 2-(trans-2-Hydroxycyclopentylamino)-1,7-bis(phenylmethyl)purin-6-one

HRID 275341Notes

Reaction equation

HRID 275341 reaction equation
Cl[C:2]1[N:3]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1.[NH2:26][C@@H:27]1[CH2:31][CH2:30][CH2:29][C@H:28]1[OH:32]>>[OH:32][C@@H:28]1[CH2:29][CH2:30][CH2:31][C@H:27]1[NH:26][C:2]1[N:3]([CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:4](=[O:18])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 10464306rac-(1R,2R)-2-aminocyclopentan-1-olHCID 200878862-Chloro-1,7-bis(phenylmethyl)purin-6-one

Product 1

HCID 542556752-(trans-2-Hydroxycyclopentylamino)-1,7-bis(phenylmethyl)purin-6-one

Procedure

Treat 2-chloro-1,7-bis(phenylmethyl)purin-6-one with trans-2-aminocyclopentanol as described in Preparative Example 5 to give the title compound, a tan solid. FAB MS: M+1=416.

Sources & evidence

ORD record
ord-0f9be29703234980a8e05c1bdd3b9ada
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

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