Hydrochloric Acid → HCID 178445045, compound

HRID 275568Notes

Reaction equation

[PH:1](=[O:4])([OH:3])[OH:2].[CH2:5]([CH:7]([CH2:35][CH3:36])[CH:8]1[O:34][CH:9]1[C:10]1[N:14]=[CH:13][N:12](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:11]=1)[CH3:6].[ClH:37]>>[PH:1](=[O:2])([OH:4])[OH:3].[CH2:5]([CH:7]([CH2:35][CH3:36])[CH:8]([OH:34])[CH:9]([Cl:37])[C:10]1[N:14]=[CH:13][NH:12][N:11]=1)[CH3:6]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 178442325HCID 178442325, compound

Product 1

HCID 178445045HCID 178445045, compound

Procedure

Diethyl (2RS,3RS)-2,3-epoxy-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate (0.39 g, prepared as described in Example 52) was treated with hydrochloric acid, as described in Example 53 for the (RS,SR) isomer, to give diethyl (2RS, 3RS)-3-chloro-2-hydroxy-3(1,2,4-triazol-3-yl)propane phosphonate (0.21 g) as a colourless oil, probably as its hydrochloride. NMR(D2O): δ1.15(6H,t), 2.15(2H,m), 4.00(4H,m), 4.45(1H,m), 5.17(1H,d), 8.75(1H,s). (No internal standard, solvent signal at δ4.67).

Sources & evidence

ORD record: ord-e5ac5473e77849dc80700ad2c0bd3f4c
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05393732

Reaction notes

Loading…