反应详情

Diethyl 3-hydroxy-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate (1.0 g, prepared as described in Example 24) was acylated with bromoacetyl bromide (0.50 g) in a manner similar to the acetylation described in Example 26. Diethyl 3(bromoacetoxy)-3(1-trityl-1,2,4-triazol-3-yl)propane phosphonate (0.40 g) was isolated as a colourless gum. NMR (CDCl3): δ 1.3(6H,t), 1.7-1.9(2H,m), 2.3(2H,m), 3.8-3.95(2H,m), 4.1(4H,m), 6.0(1H,t), 7.1-7.3(15H,m), 7.9(1H,2xs). FAB M/S: MH+ 626,628. IR: 1746 cm-1 carbonyl.