HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 178511792, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | (1S,2R,3S)-3-amino-1-cyclopropyl-4-phenyl-1,2-butanediol | HCID 22861541 | — |
| Reactant | N,1-Bis(((9H-fluoren-9-yl)methoxy)carbonyl)-L-histidine | HCID 45072174 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178511792 | HCID 178511792 | — |
Reaction Steps
In an analogous manner to that described in Example 1, paragraph (c), by the condensation of Fmoc-His(Fmoc)-OH and (1S,2R,3S)-3-amino-1-cyclopropyl-4-phenyl-1,2-butanediol followed by cleavage of the protecting groups using piperidine in methylene chloride there was obtained (S)-α-amino-N-[(1S,2R,3S)-1-benzyl-3-cyclopropyl-2,3-dihydroxypropyl]-imidazole-4-propionamide as a colourless foam, MS: 359 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393875 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-85825bc2028846508d63b6015bf237e0 |
| Source note | uspto-grants-1995_02 |