Hydrogen Bromide → HCID 18315899, compound

HRID 275747Notes

Reaction equation

HRID 275747 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]([CH2:18][CH2:19]O)[C:16](=[O:21])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[BrH:22]>O>[BrH:22].[Br:22][CH2:19][CH2:18][N:17]1[C:16](=[O:21])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]1[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 18315898HCID 18315898, compound

Product 1

HCID 18315899HCID 18315899, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 2-(4-chlorophenyl)-3-(2-hydroxyethyl)-4(3H)-quinazolinone (0.068 mol) and HBr in water 46% (200 ml) was stirred and refluxed for 90 minutes. 300 ml of water was added. The crystallized product was filtered off and dried (fraction 1). The filtrate (oil) was solidified (fraction 2). Both fractions were combined, yielding 23.5 g (78%) of 3-(2-bromoethyl)-2-(4-chlorophenyl)-4(3H)-quinazolinone monohydrobromide; mp. 214.0° C. (interm. 19).

Workup

  1. temperaturerefluxed for 90 minutes
  2. filtrationThe crystallized product was filtered off
  3. customdried (fraction 1)

Sources & evidence

ORD record
ord-205b9c728bd5418badeeb6872763d262
Source dataset
uspto-grants-2002_03
Patent number
US06352999B1

Reaction notes

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