Sodium borohydride → 2-Amino-alpha-(3-tert-butoxycarbonylaminomethylphenyl)-5-isobutyloxybenzyl alcohol

Participants

Reaction Steps

In methanol (12 ml) was dissolved 2-amino-3′-tert-butoxycarbonylaminomethyl-5-isobutyloxy-benzophenone (0.38 g). To the solution was added, while stirring at room temperature, sodium borohydride (50 mg). The reaction mixture was concentrated, to which was added water, followed by extraction with ethyl acetate (50 ml). The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave 2-amino-α-(3-tert-butoxycarbonylaminomethylphenyl)-5-isobutyloxy-benzyl alcohol as a yellow oily product (0.36 g).

Provenance & Evidence