Hydrochloric Acid → HCID 178494701, compound

HRID 275901Notes

Reaction equation

HRID 275901 reaction equation
N[C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1.Cl.N([O-])=[O:15].[Na+]>O>[OH:15][C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 178494689HCID 178494689, compound

Product 1

HCID 178494701HCID 178494701, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

2-amino-4-hydroxy-6-methoxymethyl-5-methylpyrimidine (2.7 g, 16 mmol) was added to 20% aqueous hydrochloric acid solution (7 ml), and heated to 70° C. A solution of sodium nitrite (2.3 g, 33.3 mmol) in water was added dropwise to a reaction mixture while maintaining the reaction temperature under 70° C. The reaction mixture was cooled to a room temperature. The resulting solid was filtered and dried to give 1.5 g of the titled compound.

Workup

  1. temperaturewhile maintaining the reaction temperature under 70° C
  2. temperatureThe reaction mixture was cooled to a room temperature
  3. filtrationThe resulting solid was filtered
  4. customdried

Sources & evidence

ORD record
ord-03a96151fb5f478b94ae171dae7024a8
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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